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LOCALIZATION OF THE SEX-DETERMINING REGION-Y GENE IN XX MALES
- Source :
- Systems Biology in Reproductive Medicine; 2000, Vol. 44 Issue: 2 p133-136, 4p
- Publication Year :
- 2000
-
Abstract
- Localization of the sex-determining region Y (SRY) was investigated in 2 XX males. Metaphase chromosomes from peripheral lymphocytes were stained by fluorescence in situ hybridization using DXZ1 and SRY probes. An identical hybridization signal with the SRY probe was found on an X chromosome in both cases. The karyotype of the 2 cases was 46,XX, t(X;Y)(p22.3;p11.3). It would appear that XX male is the presence of a Y-chromosome fragment transferred to the X-chromosome short arm by unequal interchange between homologous regions in the short arms of sex chromosomes.
Details
- Language :
- English
- ISSN :
- 19396368 and 19396376
- Volume :
- 44
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Systems Biology in Reproductive Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs310964
- Full Text :
- https://doi.org/10.1080/014850100262308