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LOCALIZATION OF THE SEX-DETERMINING REGION-Y GENE IN XX MALES

Authors :
Suzuki, Y.
Sasagawa, I.
Yazawa, H.
Tateno, T.
Nakada, T.
Saito, H.
Hiroi, M.
Source :
Systems Biology in Reproductive Medicine; 2000, Vol. 44 Issue: 2 p133-136, 4p
Publication Year :
2000

Abstract

Localization of the sex-determining region Y (SRY) was investigated in 2 XX males. Metaphase chromosomes from peripheral lymphocytes were stained by fluorescence in situ hybridization using DXZ1 and SRY probes. An identical hybridization signal with the SRY probe was found on an X chromosome in both cases. The karyotype of the 2 cases was 46,XX, t(X;Y)(p22.3;p11.3). It would appear that XX male is the presence of a Y-chromosome fragment transferred to the X-chromosome short arm by unequal interchange between homologous regions in the short arms of sex chromosomes.

Details

Language :
English
ISSN :
19396368 and 19396376
Volume :
44
Issue :
2
Database :
Supplemental Index
Journal :
Systems Biology in Reproductive Medicine
Publication Type :
Periodical
Accession number :
ejs310964
Full Text :
https://doi.org/10.1080/014850100262308