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Pregnancy Outcome and Prognosisin Fetuses with Increased First-TrimesterNuchal Translucency

Authors :
Mangione, Raphaële
Guyon, Frédéric
Taine, Laurence
Wen, Zong Qi
Roux, Denis
Vergnaud, Armand
Maugey-Laulom, Brigitte
Horovitz, Jacques
Saura, Robert
Source :
Fetal Diagnosis and Therapy; December 2001, Vol. 16 Issue: 6 p360-363, 4p
Publication Year :
2001

Abstract

AbstractObjective:One of the concerns of prenatal diagnosis is to find sensitive markers to screen for chromosome abnormalities, such as serum assays or nuchal translucency (NT). This study reports our experience with NT measurement during the first trimester of pregnancy. Materials:The study was performed prospectively on 252 fetuses with either NT ≥3 mm or cystic hygroma. Results:We observed 50 abnormal karyotypes, i.e. 19.8%. The incidence of chromosome abnormalities increased with increasing maternal age and increasing NT thickness. For the 202 fetuses with normal karyotypes, outcome was unfavourable in 32 cases: 23 elective terminations of pregnancy, 8 spontaneous abortions and 1 neonatal death. Outcome was favourable in 141 cases. Twenty-nine pregnancies were lost to follow-up. Conclusion:Measurement of NT at 12 weeks’ gestation seems to be a good marker for chromosome abnormalities. When the karyotype is normal, the pregnancy outcome remains correlated with the degree of NT thickness. The finding of NT >3 mm between 10 and 14 weeks’ gestation dictates rigorous ultrasound monitoring and caution when predicting pregnancy outcome.Copyright © 2001 S. Karger AG, Basel

Details

Language :
English
ISSN :
10153837 and 14219964
Volume :
16
Issue :
6
Database :
Supplemental Index
Journal :
Fetal Diagnosis and Therapy
Publication Type :
Periodical
Accession number :
ejs30987358
Full Text :
https://doi.org/10.1159/000053941