Mechanisms and Rescue Strategies of Calcineurin Inhibitor Mediated Tolerance Abrogation Induced by Anti‐CD4 mAb Treatment

Authors :: Siepert, A.
Brösel, S.
Vogt, K.
Ahrlich, S.
Schmitt‐Knosalla, I.
Loddenkemper, C.
Kühl, A.
Baumgrass, R.
Gerstmayer, B.
Tomiuk, S.
Tiedge, M.
Viklický, O.
Brabcova, I.
Nizze, H.
Lehmann, M.
Volk, H.‐D.
Sawitzki, B.
Source :: American Journal of Transplantation; September 2013, Vol. 13 Issue: 9 p2308-2321, 14p
Publication Year :: 2013
Abstract: Transient coapplication of cyclosporine A abrogates CD4‐specific monoclonal antibody‐mediated transplant tolerance by inducing intragraft CXCL13 expression leading to B cell attraction, alloantibody production and complement‐mediated tissue destruction.

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