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Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
- Source :
- Molecular Biology of the Cell; December 2012, Vol. 23 Issue: 23 p4484-4494, 11p
- Publication Year :
- 2012
-
Abstract
- HMGCR is subject to Insig-dependent, sterol-accelerated ERAD. gp78 was reported to target HMGCR and Insig-1 for ubiquitination and degradation. Here gp78-mediated Insig-1 degradation is confirmed, but no role for gp78 is found in regulated ERAD of HMGCR. The identity of the HMGCR E3(s) and mechanistic details of HMGCR degradation await further study.
Details
- Language :
- English
- ISSN :
- 10591524 and 19394586
- Volume :
- 23
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Molecular Biology of the Cell
- Publication Type :
- Periodical
- Accession number :
- ejs29061028
- Full Text :
- https://doi.org/10.1091/mbc.e12-08-0631