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Hypomethylation of the IL17RCPromoter Associates with Age-Related Macular Degeneration
- Source :
- Cell Reports; November 2012, Vol. 2 Issue: 5 p1151-1158, 8p
- Publication Year :
- 2012
-
Abstract
- Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RCpromoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RCpromoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RCmay potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 2
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs29030168
- Full Text :
- https://doi.org/10.1016/j.celrep.2012.10.013