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In Vitro Evaluation of Chelate-Setting Cements Fabricated from Silicon-Containing Apatite Powder Using Osteoblastic Cells
- Source :
- Key Engineering Materials; November 2012, Vol. 529 Issue: 1 p183-186, 4p
- Publication Year :
- 2012
-
Abstract
- n our previous study, silicon-containing hydroxyapatite (Si-HAp) powder was prepared via an aqueous precipitation reaction. The Si-HAp powders were synthesized with desired Si contents (0, 0.4, 0.8, 1.6, and 2.4 mass%) as a nominal composition. Another previous study in our group demonstrated surface-modification of HAp powder with inositol phosphate (IP6) enhanced the compressive strength of apatite cement. Thus, to fabricate the cements with higher bioactivity, the above Si-HAp powders were surface-modified with IP6 (IP6-Si-HAp). The IP6-Si-HAp cements with various Si contents were fabricated by mixing with pure water at the powder/liquid ratio of 1/0.4 [w/v]. In order to clarify biocompatibility of the IP6-Si-HAP cements in the present work, MC3T3-E1 cells as a model of osteoblast were seeded on the cement specimens. As for the numbers of cells cultured on the IP6-Si-HAp cements, the substitution of lower levels of Si into HAp lattice did not greatly influence the cell proliferation. However, the substitution of Si amount over 0.8 mass% enhanced the cell proliferation. Especially, the IP6-Si-HAp cement with the Si content of 2.4 mass% showed excellent cell proliferation among examined specimens. Therefore, to fabricate the cements with higher bioactivity, it is necessary to control the amount of Si in the IP6-Si-HAp cements. The usage of these IP6-Si-HAp cements may make it possible to fabricate the cements with higher bioactivity, compare to conventional pure HAp cements.
Details
- Language :
- English
- ISSN :
- 10139826 and 16629795
- Volume :
- 529
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Key Engineering Materials
- Publication Type :
- Periodical
- Accession number :
- ejs29017889
- Full Text :
- https://doi.org/10.4028/www.scientific.net/KEM.529-530.183