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Insulinlike Growth Factor I Immunoreactivity in Nasal Polyps

Authors :
Petruson, Björn
Hansson, Hans-Arne
Petruson, Karin
Source :
Archives of Otolaryngology-Head & Neck Surgery; November 1988, Vol. 114 Issue: 11 p1272-1275, 4p
Publication Year :
1988

Abstract

• Nasal polyps from 15 patients were all found to express increased insulinlike growth factor I immunoreactivity. A hypothesis for the formation of nasal polyps is described: macrophages, seen in allergic and infectious reactions, produce and release growth factors, tentatively including insulinlike growth factor I. In enclosed paranasal sinuses this results in an accumulation of insulinlike growth factor I stimulating the growth of both epithelium and blood vessels in the sinuses. The mucosa increasingly bulges out through the ostium after having filled out the sinusity. Continuing growth stimulation is supplied by the inflammatory reaction, endothelial cells in the polyp, and activated macrophages inside or outside the polyp.(Arch Otolaryngol Head Neck Surg 1988;114:1272-1275)

Details

Language :
English
ISSN :
08864470 and 1538361X
Volume :
114
Issue :
11
Database :
Supplemental Index
Journal :
Archives of Otolaryngology-Head & Neck Surgery
Publication Type :
Periodical
Accession number :
ejs28599026
Full Text :
https://doi.org/10.1001/archotol.1988.01860230066026