Trazodone-Induced Palinopsia

• Palinopsia refers to the persistence or reappearance of an image of a recently viewed object. Typically, patients with palinopsia have other visual symptoms or signs, and the underlying cause is a structural lesion of the posterior portions of the cerebral hemispheres. However, we treated three patients who experienced palinopsia as an isolated symptom, apparently as a side effect of trazodone hydrochloride therapy for depression. The palinopsia was dose related and disappeared with reduction or cessation of therapy.