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Inhibition of Blood-Aqueous Humor Barrier Breakdown With Diclofenac: A Fluorophotometric Study
- Source :
- Archives of Ophthalmology; March 1990, Vol. 108 Issue: 3 p380-383, 4p
- Publication Year :
- 1990
-
Abstract
- • Various doses of a new topical nonsteroidal anti-inflammatory agent, diclofenac sodium, were tested against prednisolone sodium phosphate in a randomized double-masked study to determine comparative efficacy and safety regarding the reduction of postsurgical ocular inflammation. Inflammation was assessed by measuring fluorescein leakage into the anterior chamber using f luorophotometry techniques. Increased leakage in each patient's operated-on eye compared with the unoperated-on control eye was attributed to a breakdown in the blood-aqueous barrier caused by the cataract surgery. Elimination or significant reduction of fluorescein leakage within a treatment group constituted increased efficacy in controlling inflammation. A total of 124 cases were analyzed. There were no preoperative differences among groups in fluorescein leakage. At 1 week after surgery, all three diclofenac groups had significantly less fluorescein leakage compared with the prednisolone group. Mean percent increases were 56% to 118% in diclofenac groups vs 324% in the prednisolone group. No differences among diclofenac concentrations were detected. The differences between prednisolone and diclofenac were also present, although of lesser magnitude, at 3 weeks. This demonstration of increased efficacy of the nonsteroidal anti-inflammatory agent vs prednisolone is promising given the known side effects of ocular steroids.
Details
- Language :
- English
- ISSN :
- 00039950 and 15383601
- Volume :
- 108
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Archives of Ophthalmology
- Publication Type :
- Periodical
- Accession number :
- ejs28583640
- Full Text :
- https://doi.org/10.1001/archopht.1990.01070050078035