Resistance to Voriconazole Due to a G448S Substitution in Aspergillus fumigatusin a Patient with Cerebral Aspergillosis

ABSTRACTA voriconazole-resistant isolate of Aspergillus fumigatuswas recovered from an immunocompetent patient receiving long-term antifungal therapy for cerebral aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was identified as the cause of the resistance phenotype. This article describes the first isolation of a voriconazole-resistant A. fumigatusisolate from an immunocompetent patient in Spain.