Back Cover: Insights into the Mechanism of the Antibiotic‐Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes (Angew. Chem. Int. Ed. 17/2012)

New antibioticsare needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus(MRSA). The initiating step of the biosynthesis of the next‐generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose‐phosphate‐isomerase barrel structure as was shown by E. Oldfield, R.‐T. Guo, and co‐workers in their Communication on page 4157 ff.The transferred farnesyl group undergoes a trans‐to‐cisconversion in its first double bond.