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Cross double Mannich reaction catalyzed by I2: Synthesis of highly substituted 4-piperidones
- Source :
- Chinese Chemical Letters; March 2012, Vol. 23 Issue: 3 p309-312, 4p
- Publication Year :
- 2012
-
Abstract
- Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions, yielding a series of highly substituted 4-piperidones. Among the possible diastereomers, only one diastereomer was isolated, which could be ascribed to the chair-like transition state in six-membered ring, in which all of the hindered groups are located in the pseudoequatorial orientation.
Details
- Language :
- English
- ISSN :
- 10018417
- Volume :
- 23
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs26866540
- Full Text :
- https://doi.org/10.1016/j.cclet.2011.12.008