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Design, Synthesis and In Vitro Antimalarial Evaluation of New Quinolinylhydrazone Derivatives
- Source :
- Letters in Drug Design & Discovery; February 2012, Vol. 9 Issue: 2 p163-168, 6p
- Publication Year :
- 2012
-
Abstract
- A series of novel quinolinylhydrazones (5a-f) was synthesized by the condensation reaction of 2,6-diarylsubstituted piperidin-4-ones (4a-f) with 7-chloro-4-hydrazinoquinoline (2). Novel quinolinylhydrazones containing Shiff bases 8a-f and 11a-f were obtained via the condensation of Shiff bases 7a-f and 10a-f with 7-chloro-4-hydrazinoquinoline. These synthesized hydrazones were screened for their in vitro antimalarial activities to chloroquine - sensitive (T96) and chloroquine - resistant (K1) strains of P.falciparum. Among the synthesized compounds, 11a exhibited strong antimalarial activity at IC50 of 103.4 ng/mL and 18.76 ng/mL to both strains of P.falciparum, respectively.
Details
- Language :
- English
- ISSN :
- 15701808
- Volume :
- 9
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Letters in Drug Design & Discovery
- Publication Type :
- Periodical
- Accession number :
- ejs26679952