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ChemInform Abstract: Design, Synthesis and Evaluation of New α‐Nucleophiles for the Hydrolysis of Organophosphorus Nerve Agents: Application to the Reactivation of Phosphorylated Acetylcholinesterase.

Authors :
Saint‐Andre, Geraldine
Kliachyna, Maria
Kodepelly, Sanjeevarao
Louise‐Leriche, Ludivine
Gillon, Emilie
Renard, Pierre‐Yves
Nachon, Florian
Baati, Rachid
Wagner, Alain
Source :
ChemInform; December 2011, Vol. 42 Issue: 52 pno-no
Publication Year :
2011

Abstract

A variety of (het)aryl aldoximes, (het)arylamidoximes and hydroxamic acids, e.g. (I), is tested as nucleophilic agent for the hydrolysis of phenylphosphonothioate (PhX), a member of a class of organophosphorus used as chemical warfare agents.

Details

Language :
English
ISSN :
09317597 and 15222667
Volume :
42
Issue :
52
Database :
Supplemental Index
Journal :
ChemInform
Publication Type :
Periodical
Accession number :
ejs26384703
Full Text :
https://doi.org/10.1002/chin.201152199