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Molecular cloning of a cDNA encoding human antihaemophilic factor

Authors :
Toole, John J.
Knopf, John L.
Wozney, John M.
Sultzman, Lisa A.
Buecker, Janet L.
Pittman, Debra D.
Kaufman, Randal J.
Brown, Eugene
Shoemaker, Charles
Orr, Elizabeth C.
Amphlett, Godfrey W.
Foster, W. Barry
Coe, Mary Lou
Knutson, Gaylord J.
Fass, David N.
Hewick, Rodney M.
Source :
Nature; November 1984, Vol. 312 Issue: 5992 p342-347, 6p
Publication Year :
1984

Abstract

A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.

Details

Language :
English
ISSN :
00280836 and 14764687
Volume :
312
Issue :
5992
Database :
Supplemental Index
Journal :
Nature
Publication Type :
Periodical
Accession number :
ejs25251762
Full Text :
https://doi.org/10.1038/312342a0