Effect of Acetazolamide on the Chloride Shift and the Sodium Pump in Secretory Cells

AN active chloride pump has been suggested as the chief driving force for the process of secretion by human sweat glands1. Such a mechanism has been used as an important premise in a hypothesis to describe the basic defect in cystic fibrosis2. Because the evidence for such a pump in the sweat gland is very weak we have reinvestigated this problem to find out whether our concept of a sodium pump3should be revised, or whether some alternative mechanism should be suggested.