Localization of Tumours and Drugs on the Chorio-allantoic Membrane of the Chick Embryo

BECAUSE the chick embryo is immunologically immature during the first two weeks of its development, heterologous tissues such as human and rat tumours can be grown on the highly vascular chorio-allantoic membrane (CAM) of this organism without the necessity of pre-treating it in order to suppress the immune response. Tumours grown in this way have been used to assess the effects of potential anti-tumour drugs1–6.