Antitussive Activity of Medazonamide

MOST of the known antitussive agents also possess, in varying degree, other pharmacological properties, such as the analgesic, antihistaminic, local anaesthetic and spasmolytic ones (Silvestrini and Maffii1). These activities are often responsible for, or directly connected with, specific clinical side effects that may limit the effect. In particular, the antitussives that show analgesic effect produce depression of respiration and possibly tolerance, while antihistaminic antitussives often lead to drowsiness, and the local anaesthetic ones usually have a high toxicity.