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Cloning and initial characterization of human and mouse Spot 14 genes 1Nucleotide sequences of the Mus musculusand Homo sapiensSpot 14 genes have been submitted to the EMBL Data Bank under the accession numbers X95279 and Y08409, respectively. 1
- Source :
- FEBS Letters; January 1997, Vol. 401 Issue: 1 p38-42, 5p
- Publication Year :
- 1997
-
Abstract
- The intricate regulation of Spot 14 expression in rat lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription. To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region. The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 401
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- FEBS Letters
- Publication Type :
- Periodical
- Accession number :
- ejs2502370
- Full Text :
- https://doi.org/10.1016/S0014-5793(96)01433-0