Regulation of COX‐2 Expression in Canine Prostate Carcinoma: Increased COX‐2 Expression is Not Related to Inflammation

Background: Cyclooxygenase‐2 (COX‐2) expression has been documented in human and canine prostate carcinoma (PCA). Canine PCA is a histologically heterogeneous tumor, sometimes including inflammatory infiltrates. However, it is unknown whether COX‐2 expression in canine PCA is related to the histologic type of tumor, to the presence of inflammation, or to both. Moreover, little is known about the mechanisms regulating COX‐2 expression in neoplastic tissue.