Temporal and Spatial Expression Profiles of BMP Receptors and Noggin During BMP‐2‐Induced Ectopic Bone Formation

The mechanism of ectopic bone formation has not been clear. After BMP‐2 implantation into the back muscles of 198 mice, expression of BMPR‐1A,–2, and Noggin was increased during the early phase of the reaction. The results suggest that positive and negative feedback mechanisms modulate ectopic osteogenesis induced by this growth factor.