Impaired Fracture Healing in the Absence of TNF‐α Signaling: The Role of TNF‐α in Endochondral Cartilage Resorption

TNF‐α is a major inflammatory factor that is induced in response to injury, and it contributes to the normal regulatory processes of bone resorption. The role of TNF‐α during fracture healing was examined in wild‐type and TNF‐α receptor (p55−/−/p75−/−)‐deficient mice. The results show that TNF‐α plays an important regulatory role in postnatal endochondral bone formation.