Cdx‐2 Polymorphism in the Promoter Region of the Human Vitamin D ReceptorGene Determines Susceptibility to Fracture in the Elderly

A Cdx‐2 binding site polymorphism (G to A) in the promoter region of the human vitamin D receptorgene was reported. In an ecological study in eight ethnic groups and an association study in 2848 elderly whites, we found the A‐allele to be associated with decreased fracture risk. Our findings expand previous similar findings in a Japanese study to whites and show a relationship with fracture risk of this functional polymorphism.