Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC

Authors :: Friedland, Werner
Dingfelder, Michael
Kundrát, Pavel
Jacob, Peter
Source :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; June 2011, Vol. 711 Issue: 1-2 p28-40, 13p
Publication Year :: 2011
Abstract: This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fibroblasts and lymphocytes in atomic resolution. Calculation methods and essential results are recapitulated regarding the physical, physico-chemical and chemical stage of track structure development of radiation damage induction. Recent model extension towards DNA repair processes extends the time dimension by about 12 orders of magnitude and paves the way for superior predictions of radiation risks.

Language :: English
ISSN :: 13861964
Volume :: 711
Issue :: 1-2
Database :: Supplemental Index
Journal :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publication Type :: Periodical
Accession number :: ejs24112332
Full Text :: https://doi.org/10.1016/j.mrfmmm.2011.01.003

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