Back to Search
Start Over
Cytochrome P450 3A4 Inhibitory Constituents of the Wood of Taxus yunnanensis
- Source :
- Journal of Natural Products; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4′-hydroxy-6,3′-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7-hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, α-conidendrin (12) showed strong CYP3A4 inhibition with an IC50value of 0.2 μM.
Details
- Language :
- English
- ISSN :
- 01633864 and 15206025
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Natural Products
- Publication Type :
- Periodical
- Accession number :
- ejs22740442
- Full Text :
- https://doi.org/10.1021/np100665j