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Synthesis of 3,4-Dihydro-2H-1,2,4-benzo- thiadiazine 1,1-Dioxide Derivatives as Potential Allosteric Modulators of AMPA/Kainate Receptors
- Source :
- Journal of Medicinal Chemistry; June 2002, Vol. 45 Issue: 12 p2355-2357, 3p
- Publication Year :
- 2002
-
Abstract
- A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.
Details
- Language :
- English
- ISSN :
- 00222623 and 15204804
- Volume :
- 45
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs2247850
- Full Text :
- https://doi.org/10.1021/jm025510d