Efficient one-pot synthesis of N-ethyl amino acids

Authors :: Rückle, Thomas
Dubray, Benoit
Hubler, Francis
Mutter, Manfred
Source :: Journal of Peptide Science; January 1999, Vol. 5 Issue: 1 p56-58, 3p
Publication Year :: 1999
Abstract: Mono-N-ethylated α-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc)<INF>3</INF>. The elaborated one-pot synthesis allows for the efficient synthesis of side-chain protected amino acid derivatives. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.

Language :: English
ISSN :: 10752617 and 10991387
Volume :: 5
Issue :: 1
Database :: Supplemental Index
Journal :: Journal of Peptide Science
Publication Type :: Periodical
Accession number :: ejs2201707
Full Text :: https://doi.org/10.1002/(SICI)1099-1387(199901)5:1<56::AID-PSC186>3.0.CO;2-J