Mechanistic Insights into the One‐Pot Synthesis of Propargylamines from Terminal Alkynes and Amines in Chlorinated Solvents Catalyzed by Gold Compounds and Nanoparticles

Propargylamines can be obtained from secondary amines and terminal alkynes in chlorinated solvents by a three‐ and two‐component synthesis catalyzed by gold compounds and nanoparticles (Au‐NP) under mild conditions. The use of dichloromethane allows for the activation of two CCl bonds and a clean transfer of the methylene fragment to the final product. The scope of the reaction as well as the influence of different gold(III) cycloaurated complexes and salts has been investigated. The involvement of gold nanoparticles generated in situ in the process is discussed and a plausible reaction mechanism is proposed on the basis of the data obtained.