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Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor
- Source :
- Organic Process Research & Development; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- A highly convergent synthesis of c-Met kinase inhibitor 1has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1were isolated in seven steps (the longest linear sequence).
Details
- Language :
- English
- ISSN :
- 10836160 and 1520586X
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Organic Process Research & Development
- Publication Type :
- Periodical
- Accession number :
- ejs21561828
- Full Text :
- https://doi.org/10.1021/op100101q