A study on the selective phosphorylation and phosphinylation of hydroxyphenols

By choice of appropriate reaction conditions, the phosphorylation of hydroquinone by diethyl chlorophosphate gave predominantly the monophosphate (2). A similar reaction of phloroglucinol led to the mixture of the possible products (6, 7, and 8). The monophosphinylation of the above hydroxyphenols by diphenylphosphinyl chloride could be accomplished with a good selectivity to give product 4or 9, the yields, however, being variable. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:126–130, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10006