Antimicrobial treatment for early, limited Mycobacterium ulceransinfection: a randomised controlled trial

Surgical debridement was the standard treatment for Mycobacterium ulceransinfection (Buruli ulcer disease) until WHO issued provisional guidelines in 2004 recommending treatment with antimicrobial drugs (streptomycin and rifampicin) in addition to surgery. These recommendations were based on observational studies and a small pilot study with microbiological endpoints. We investigated the efficacy of two regimens of antimicrobial treatment in early-stage M ulceransinfection.