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In-vivo activity and tolerance of conventional formulation versus fat emulsion formulation of amphotericin B in experimental disseminated candidiasis in neutropenic rabbits.
- Source :
- Journal of Antimicrobial Chemotherapy (JAC); March 1997, Vol. 39 Issue: 3 p427-430, 4p
- Publication Year :
- 1997
-
Abstract
- Amphotericin B can cause significant toxicity but this can be reduced by direct dilution into a fat emulsion (Intralipid). To investigate the potential use of amphotericin B diluted in Intralipid, a study was made of its activity in the treatment of subacute disseminated candidiasis in persistently granulocytopenic rabbits, compared with the same dose of amphotericin B diluted in dextrose. Amphotericin-B-fat emulsion was at least as effective as amphotericin-B-dextrose. Amphotericin-B-fat emulsion was significantly more effective than amphotericin-B-dextrose therapy in reducing candida colony counts in both kidney and liver tissues (P < 0.05). Furthermore, amphotericin-B-fat emulsion was found less toxic on the renal function than conventional amphotericin B (P < 0.05). From these experimental results, we conclude that amphotericin-B-fat emulsion (Intralipid) was at least as effective and less toxic than conventional amphotericin B.
Details
- Language :
- English
- ISSN :
- 03057453 and 14602091
- Volume :
- 39
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Periodical
- Accession number :
- ejs20236665
- Full Text :
- https://doi.org/10.1093/jac/39.3.427