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A Sub‐50‐nm Monosized Superparamagnetic Fe3O4@SiO2T2‐Weighted MRI Contrast Agent: Highly Reproducible Synthesis of Uniform Single‐Loaded Core–Shell Nanostructures
- Source :
- Chemistry - An Asian Journal; December 2009, Vol. 4 Issue: 12 p1809-1816, 8p
- Publication Year :
- 2009
-
Abstract
- Oleic acid stabilized superparamagnetic iron oxide nanoparticles (SPION) were selected as the cores for fabrication of sub‐50‐nm monodisperse single‐loaded SPION@SiO2core–shell nanostructures. Parameters that influence the formation of SPION@SiO2in the water‐in‐oil reverse microemulsion system have been systematically investigated. The sufficiently high concentration of well‐dispersed SPION, together with an appropriately low injection rate of tetraethoxysilane, were found to be the keys to efficiently prevent the homogeneous nucleation of silica and obtain a high‐quality single‐loaded core–shell nanocomposite. A more detailed mechanism for incorporating oleic acid capped inorganic functional nanoparticles into silica is proposed on the basis of previous reports and our new experimental results. Finally, the as‐synthesized SPION@SiO2nanospheres are exploited as an MRI‐enhanced contrast agent, and their contrast effect in solution is tested by using a clinical MRI instrument.
Details
- Language :
- English
- ISSN :
- 18614728 and 1861471X
- Volume :
- 4
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Periodical
- Accession number :
- ejs20235727
- Full Text :
- https://doi.org/10.1002/asia.200900276