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Engineering Tolerance into Transplanted ? Cell Lines
- Source :
- Annals of the New York Academy of Sciences; November 2001, Vol. 944 Issue: 1 p267-270, 4p
- Publication Year :
- 2001
-
Abstract
- In this paper we explore the possibility of improving, by genetic engineering, the resistance of insulin-secreting cells to the metabolic and inflammatory stresses that are anticipated to limit their function and survival when encapsulated and transplanted in a type 1 diabetic environment. We show that transfer of the Bcl-2 antiapoptotic gene, and of genes specifically interfering with cytokine intracellular signaling pathways, greatly improves resistance of the cells to metabolic limitations and inflammatory stresses.
Details
- Language :
- English
- ISSN :
- 00778923 and 17496632
- Volume :
- 944
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs19485516
- Full Text :
- https://doi.org/10.1111/j.1749-6632.2001.tb03838.x