Alcohol, But Not Lipopolysaccharide‐Induced Liver Apoptosis Involves Changes in Intracellular Compartmentalization of Apoptotic Regulators

Abstract: Background: While alcohol‐induced augmentation of liver apoptosis has been demonstrated in humans and laboratory animals, the underlying mechanisms are not fully elucidated. This study addresses the question whether alcohol and bacterial lipopolysaccharide (LPS), a putative mediator of alcohol effects on the liver, induce augmentation of liver apoptosis by intrinsic or extrinsic signaling pathways. This information may prove important for future design of therapies for alcoholic liver disease.