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Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL Network
- Source :
- Journal of Hematopathology; July 2009, Vol. 2 Issue: 2 p103-111, 9p
- Publication Year :
- 2009
-
Abstract
- Abstract: Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has been shown to be a very powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2 × 500 lymphoma cells is the gold standard to assess the Ki-67 index since this value has been shown to predict survival in prospective randomized trials of the European MCL Network. Estimation by eyeballing and digital image analysis showed a poor concordance with the gold standard (concordance correlation coefficients [CCC] between 0.29 and 0.61 for eyeballing and CCC of 0.24 and 0.37 for two methods of digital image analysis, respectively). Counting a reduced number of lymphoma cells (2 × 100 cells) showed high interobserver agreement (CCC = 0.74). Pitfalls of the Ki-67 index are discussed and guidelines and recommendations for assessing the Ki-67 index in MCL are given.
Details
- Language :
- English
- ISSN :
- 18689256 and 18655785
- Volume :
- 2
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Journal of Hematopathology
- Publication Type :
- Periodical
- Accession number :
- ejs19018502
- Full Text :
- https://doi.org/10.1007/s12308-009-0036-x