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Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.

Authors :
Xiao, Q
Claassen, G
Shi, J
Adachi, S
Sedivy, J
Hann, S R
Source :
Genes & Development; December 1998, Vol. 12 Issue: 24 p3803-3808, 6p
Publication Year :
1998

Abstract

Transcriptional activation by c-Myc through specific E box elements is thought to be essential for its biological role. However, c-MycS is unable to activate transcription through these elements and yet retains the ability to stimulate proliferation, induce anchorage-independent growth, and induce apoptosis. In addition, c-MycS retains the ability to repress transcription of several specific promoters. Furthermore, c-MycS can rescue the c-myc null phenotype in fibroblasts with homozygous deletion of c-myc. Taken together, our data argue against the paradigm that all of the biological functions of c-Myc are mediated by transcriptional activation of specific target genes through E box elements.

Details

Language :
English
ISSN :
08909369 and 15495477
Volume :
12
Issue :
24
Database :
Supplemental Index
Journal :
Genes & Development
Publication Type :
Periodical
Accession number :
ejs18910381