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Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.
Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis.
- Source :
- Genes & Development; December 1998, Vol. 12 Issue: 24 p3803-3808, 6p
- Publication Year :
- 1998
-
Abstract
- Transcriptional activation by c-Myc through specific E box elements is thought to be essential for its biological role. However, c-MycS is unable to activate transcription through these elements and yet retains the ability to stimulate proliferation, induce anchorage-independent growth, and induce apoptosis. In addition, c-MycS retains the ability to repress transcription of several specific promoters. Furthermore, c-MycS can rescue the c-myc null phenotype in fibroblasts with homozygous deletion of c-myc. Taken together, our data argue against the paradigm that all of the biological functions of c-Myc are mediated by transcriptional activation of specific target genes through E box elements.
Details
- Language :
- English
- ISSN :
- 08909369 and 15495477
- Volume :
- 12
- Issue :
- 24
- Database :
- Supplemental Index
- Journal :
- Genes & Development
- Publication Type :
- Periodical
- Accession number :
- ejs18910381