AllinOne TargetCellSpecific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA DeliveryThis research was supported by the National Research Laboratory Program M10600000255 for J.C. and N01080127 for T.G.P., AFOSR FA48690814046, NCI Center for Cancer Nanotechnology Excellence CCNE, NCRC R152004024000000, the Ministry of Health, Welfare, and Family Affairs N04080181, the Korea Research Council of Fundamental Science & Technology, and the secondstage BK21 project for chemistry at Yonsei University. siRNAsmall interfering RNA.

Cancercelltargeted gene silencingwas observed with a magneticnanoparticle platform MEIO, magnetismengineered iron oxide on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached see picture. The different functionalities enable the macroscopic magnetic resonance and microscopic fluorescence imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.