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Sex chromosome markers: Characterization using fluorescence in situ hybridization and review of the literature

Authors :
Schwartz, Stuart
Depinet, Theresa W.
Leana-Cox, Julie
Isada, Nelson B.
Karson, Evelyn M.
Park, Vicki M.
Pasztor, Linda M.
Sheppard, Linda C.
Stallard, Richard
Wolff, Daynna J.
Zinn, Arthur B.
Zurcher, Vickie L.
Zackowski, Joleen L.
Source :
American Journal of Medical Genetics. Part A; 11 July 1997, Vol. 71 Issue: 1 p1-7, 7p
Publication Year :
1997

Abstract

Fluorescence in situ hybridization (FISH) using biotin labeled X- and Y-chromosome DNA probes was utilized in the analysis of 23 sex chromosome-derived markers. Specimens were obtained through prenatal diagnosis, because of a presumptive diagnosis of Ullrich-Turner syndrome, mental retardation, and minor anomalies or ambiguous genitalia; three were spontaneous abortuses. Twelve markers were derived from the X chromosome and eleven from the Y chromosome; this demonstrates successfully the value and necessity of FISH utilizing DNA probes in the identification of sex chromosome markers. Both fresh and older slides, some of which had been previously G-banded, were used in these determinations. We have also reviewed the literature on sex chromosome markers identified using FISH. Am. J. Med. Genet. 71:1–7, 1997. © 1997 Wiley-Liss, Inc.

Details

Language :
English
ISSN :
15524825 and 15524833
Volume :
71
Issue :
1
Database :
Supplemental Index
Journal :
American Journal of Medical Genetics. Part A
Publication Type :
Periodical
Accession number :
ejs1857219
Full Text :
https://doi.org/10.1002/(SICI)1096-8628(19970711)71:1<1::AID-AJMG1>3.0.CO;2-1