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Sex chromosome markers: Characterization using fluorescence in situ hybridization and review of the literature
- Source :
- American Journal of Medical Genetics. Part A; 11 July 1997, Vol. 71 Issue: 1 p1-7, 7p
- Publication Year :
- 1997
-
Abstract
- Fluorescence in situ hybridization (FISH) using biotin labeled X- and Y-chromosome DNA probes was utilized in the analysis of 23 sex chromosome-derived markers. Specimens were obtained through prenatal diagnosis, because of a presumptive diagnosis of Ullrich-Turner syndrome, mental retardation, and minor anomalies or ambiguous genitalia; three were spontaneous abortuses. Twelve markers were derived from the X chromosome and eleven from the Y chromosome; this demonstrates successfully the value and necessity of FISH utilizing DNA probes in the identification of sex chromosome markers. Both fresh and older slides, some of which had been previously G-banded, were used in these determinations. We have also reviewed the literature on sex chromosome markers identified using FISH. Am. J. Med. Genet. 71:17, 1997. © 1997 Wiley-Liss, Inc.
Details
- Language :
- English
- ISSN :
- 15524825 and 15524833
- Volume :
- 71
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- American Journal of Medical Genetics. Part A
- Publication Type :
- Periodical
- Accession number :
- ejs1857219
- Full Text :
- https://doi.org/10.1002/(SICI)1096-8628(19970711)71:1<1::AID-AJMG1>3.0.CO;2-1