Organofluorosilanes as Model Compounds for 18F‐Labeled Silicon‐Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical Calculations (PET=Positron Emission Tomography)

Water stable!Radiochemists have recently discovered silicon chemistry as a tool for the introduction of 18F into biomolecules for positron emission tomography (PET) imaging. 18F‐labeled PET tracers must be stable towards defluorination under physiological conditions. Here, a theoretical model of organofluorosilane hydrolysis is developed that correlates with the experimentally determined hydrolytic half‐lives and allows estimation of the stability of newly designed compounds (see scheme).