A comparative trial of doxycycline (‘Vibramycin’) and ampicillin in the treatment of acute sinusitis

SummaryA double-blind trial of doxycycline (200 mg. on the first day followed by 100 mg. daily for a total of 7 days) and ampicillin (250 mg. 4-times daily for 7 days) in 44 cases of acute and chronic sinusitis showed significantly superior results with doxycycline: 90% of cases responded to doxycycline and 35% to ampicillin. The incidence of side-effects was low, and these were of a minor nature, in no case necessitating discontinuance of treatment. The implication of these results for the treatment of chronic bronchitis is discussed.