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Endothelial Activation Markers in Anemic Non-Dialysis Chronic Kidney Disease Patients
- Source :
- Nephron Clinical Practice; October 2008, Vol. 110 Issue: 4 pc244-c250, 7p
- Publication Year :
- 2008
-
Abstract
- AbstractBackground/Aims:Anemia in chronic kidney disease is an independent predictor of cardiovascular disease (CVD). We explored the relationship between anemia and markers of inflammation and endothelial activation in non-dialysis chronic kidney disease (ND-CKD) patients to understand this mechanism. Methods:Cross-sectional analysis was performed on 30 adult ND-CKD patients for markers of inflammation and endothelial activation using a multiplexed immunoassay. Data were analyzed according to the anemic status defined by the modified World Health Organization criteria. Results:Seventeen patients were classified as anemic. Baseline characteristics by anemic status were similar except that anemic patients were older (p = 0.006), had lower estimated glomerular filtration rate (eGFR; p = 0.01) and higher prevalence of CVD (p = 0.02). Compared to non-anemic patients, log-transformed values of fibrinogen (p = 0.012); von Willebrand factor (vWF, p = 0.008), vascular cell adhesion molecule-1 (VCAM-1, p = 0.025) and C-reactive protein (p = 0.043) were elevated in anemic patients. Serum ferritin (p = 0.93) and serum albumin (p = 0.06) were not different. Age and eGFR-adjusted logistic regression analysis showed that anemic patients had increased odds for a composite of higher median values of fibrinogen, vWF and VCAM-1 (p = 0.01, odds ratio 8.1, 95 CI 1.08–111.0). Conclusion:We report the association of anemia with elevated markers of endothelial activation in ND-CKD patients. Longitudinal studies are needed to confirm our findings.Copyright © 2008 S. Karger AG, Basel
Details
- Language :
- English
- ISSN :
- 00282766 and 16602110
- Volume :
- 110
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Nephron Clinical Practice
- Publication Type :
- Periodical
- Accession number :
- ejs17278885
- Full Text :
- https://doi.org/10.1159/000167872