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Interaction of divalent metal ions with DNA investigated by <SUP>23</SUP>Na NMR relaxation

Authors :
Marincola, Flaminia Cesare
Casu, Mariano
Saba, Giuseppe
Manetti, Cesare
Lai, Adolfo
Source :
Physical Chemistry Chemical Physics (PCCP); May 21, 2000, Vol. 2 Issue: 10 p2425-2428, 4p
Publication Year :
2000

Abstract

The interaction between Na-DNA and divalent metal cations (Mg&lt;SUP&gt;2+&lt;/SUP&gt;, Mn&lt;SUP&gt;2+&lt;/SUP&gt;, Co&lt;SUP&gt;2+&lt;/SUP&gt; and Ni&lt;SUP&gt;2+&lt;/SUP&gt;) has been investigated by &lt;SUP&gt;23&lt;/SUP&gt;Na NMR relaxation. The experimental data have been interpreted in terms of Manning&#39;s counterion condensation theory and a two-site exchange for the sodium ions. The experiments showed that Mn&lt;SUP&gt;2+&lt;/SUP&gt; affects the polyion surface atmosphere in a different way from the other metal ions. This behaviour may be due to sugar puckering transition of the DNA induced by Mn&lt;SUP&gt;2+&lt;/SUP&gt;.

Details

Language :
English
ISSN :
14639076 and 14639084
Volume :
2
Issue :
10
Database :
Supplemental Index
Journal :
Physical Chemistry Chemical Physics (PCCP)
Publication Type :
Periodical
Accession number :
ejs1715713