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A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of 1-dopa, 1-deprenyl and dopaminoagonists. Study design and short term results
- Source :
- The Italian Journal of Neurological Sciences; December 1992, Vol. 13 Issue: 9 p735-739, 5p
- Publication Year :
- 1992
-
Abstract
- On the long term Parkinson Disease (PD) treatment is often complicated by the occurrence of motor fluctuations. To find out whether early treatment of PD with levodopa, dopaminoagonists or 1-deprenyl is associated with any difference in motor fluctuations occurrence, the Italian Parkinson Study Groups initiated a multicenter, randomized study. Since November 1988, 475 patients cequiring effective treatment for idiopathic PD have been randomized to receive levodopa, dopoamine agonists or deprenyl. After 2 months of therapy, all patients evaluated with the Unified Parkinson Disease Rating Scale showed a significant amelioration. Daily living activities were more impaired in patients treated with deprenyl. Study design is presented and first resuts are discussed.
Details
- Language :
- English
- ISSN :
- 03920461 and 11265442
- Volume :
- 13
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- The Italian Journal of Neurological Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs16763200
- Full Text :
- https://doi.org/10.1007/BF02229158