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Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes
- Source :
- Experientia; September 1979, Vol. 35 Issue: 9 p1213-1215, 3p
- Publication Year :
- 1979
-
Abstract
- Time- and dose-dependent protein synthesis inhibition takes place following exposure to high doses of dimethylnitrosamine (DMN) or diethylnitrosamine (DENA) in isolated rat hepatocytes. The ability of DENA to depress protein synthesis is 5-fold higher than that of DMN. Cells inhibited by 60 min exposure to DMN or DENA, and then incubated in a nitrosamine-free medium, regain their initial rate of protein synthesis. This recovery is faster and more complete for DENA-treated cells.
Details
- Language :
- English
- ISSN :
- 00144754
- Volume :
- 35
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Experientia
- Publication Type :
- Periodical
- Accession number :
- ejs16522749
- Full Text :
- https://doi.org/10.1007/BF01963297