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Modulation of noradrenaline and neuropeptide Y (NPY) release in the pig kidney in vivo: involvement of alpha2, NPY and angiotensin II receptors
- Source :
- Naunyn-Schmiedeberg's Archives of Pharmacology; October 1989, Vol. 340 Issue: 4 p379-385, 7p
- Publication Year :
- 1989
-
Abstract
- The modulation of the release of noradrenaline (NA) and neuropeptide Y-like immunoreactivity (NPY-LI) was investigated in the pig kidney in vivo. Under control conditions a reproducible co-release of NA and NPY-LI was obtained upon stimulation of the renal nerves with 5 Hz for 1 min. Infusion of peptide YY (PYY, 1 µg/kg/min i.v.), which binds to NPY receptors, caused renal vasoconstriction and reduced the stimulation-evoked overflow of NA and NPY-LI by 24 ± 4 and 33 ± 11%, respectively (P < 0.01). The PYY effect was reversible and was absent 1 h after the infusion. The alpha<subscript>2</subscript>-adrenoceptor antagonist yohimbine (0.2 mg/kg i. v.) enhanced the overflow of NA and NPY-LI 2- to 3-fold. The angiotensin converting enzyme inhibitor captopril (5 mg/kg i. v.) did not significantly affect the overflow of NA or NPY-LI evoked by the nerve stimulation. Angiotensin II (0.5 µg/kg/min i. v.), on the other hand, induced a reversible enhancement of the overflow of both NA and NPY-LI by 71 and 77%, respectively (P<0.01). Infusion of endothelin (0.2 µg/kg/min i.v.), which reduced renal blood flow by a magnitude similar to that evoked by angiotensin II, did not significantly alter the nerve stimulation-evoked overflow of NA or NPY-LI. None of the administered drugs did significantly affect the percentage reduction in renal blood flow evoked by nerve stimulation.
Details
- Language :
- English
- ISSN :
- 00281298 and 14321912
- Volume :
- 340
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs16396842
- Full Text :
- https://doi.org/10.1007/BF00167038