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The regulation of striatal tyrosine hydroxylase

Authors :
Zivkovic, B.
Guidotti, Alessandro
Costa, Erminio
Source :
Naunyn-Schmiedeberg's Archives of Pharmacology; June 1975, Vol. 291 Issue: 2 p193-200, 8p
Publication Year :
1975

Abstract

Gamma-hydroxybutyric acid (GHBA) in doses that increased the striatal dopamine (DA) content of rat brain failed to increase the affinity of striatal tyrosine hydroxylase (TH) for its pterdine cofactor or to change the sensitivity of the enzyme to the inhibition by DA. Haloperidol (1 mg/kg) decreased the apparent K<subscript>m</subscript>of striatal TH for the pteridine cofactor. However, when GHBA was injected before haloperidol it prevented the decrease in the apparent K<subscript>m</subscript>of TH, in a dose related manner. In vitro GHBA (10<superscript>-4</superscript> M) neither changed the stimulation of the striatal adenylyl cyclase by DA nor its inhibition by haloperidol.

Details

Language :
English
ISSN :
00281298 and 14321912
Volume :
291
Issue :
2
Database :
Supplemental Index
Journal :
Naunyn-Schmiedeberg's Archives of Pharmacology
Publication Type :
Periodical
Accession number :
ejs16285270
Full Text :
https://doi.org/10.1007/BF00500049