Back to Search
Start Over
The regulation of striatal tyrosine hydroxylase
- Source :
- Naunyn-Schmiedeberg's Archives of Pharmacology; June 1975, Vol. 291 Issue: 2 p193-200, 8p
- Publication Year :
- 1975
-
Abstract
- Gamma-hydroxybutyric acid (GHBA) in doses that increased the striatal dopamine (DA) content of rat brain failed to increase the affinity of striatal tyrosine hydroxylase (TH) for its pterdine cofactor or to change the sensitivity of the enzyme to the inhibition by DA. Haloperidol (1 mg/kg) decreased the apparent K<subscript>m</subscript>of striatal TH for the pteridine cofactor. However, when GHBA was injected before haloperidol it prevented the decrease in the apparent K<subscript>m</subscript>of TH, in a dose related manner. In vitro GHBA (10<superscript>-4</superscript> M) neither changed the stimulation of the striatal adenylyl cyclase by DA nor its inhibition by haloperidol.
Details
- Language :
- English
- ISSN :
- 00281298 and 14321912
- Volume :
- 291
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs16285270
- Full Text :
- https://doi.org/10.1007/BF00500049