Oral bioavailability of CHF1194, an inclusion complex of piroxicam and β-cyclodextrin, in healthy subjects under single dose and steady-state conditions

CHF1194 is an inclusion complex of ß-cyclodextrin with the nonsteroidal anti-inflammatory drug piroxicam. In man, ß-cyclodextrin acts as a carrier of piroxicam. As the inclusion complex of piroxicam-ß-cyclodextrin is wettable and more water soluble, the absorption rate of the drug is increased whilst its other pharmacokinetic characteristics remain unchanged.