Back to Search Start Over

Some factors controlling oral morphine intake in rats

Authors :
Cappell, Howard
LeBlanc, A. E.
Source :
Psychopharmacology; September 1971, Vol. 21 Issue: 3 p192-201, 10p
Publication Year :
1971

Abstract

Rats were given the opportunity to drink morphine solution following stabilization at three levels of “passive premedication”. Compared to saline treated controls, premedicated rats consumed more morphine solution, but medication level did not significantly affect morphine intake. Premedicated rats adjusted to a reduction in morphine solution concentration by increasing fluid intake substantially, but nonpremedicated rats did not. When morphine was offered in a vehicle of isotonic saline oral consumption rose sharply in premedicated rats but not in their nonpremedicated counterparts. “Drinker” and “nondrinker” rats were identified on the basis of initial response to oral morphine. Premedication eliminated resistance to morphine drinking, but even at the expense of severe fluid deprivation, nonpremedicated nondrinkers refused morphine throughout the entire experiment.

Details

Language :
English
ISSN :
00333158 and 14322072
Volume :
21
Issue :
3
Database :
Supplemental Index
Journal :
Psychopharmacology
Publication Type :
Periodical
Accession number :
ejs16018443
Full Text :
https://doi.org/10.1007/BF00403858