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A new translocation in chronic myelogenous leukemia

Authors :
Pravtcheva, D.
Andreeva, P.
Tsaneva, R.
Source :
Human Genetics; March 1976, Vol. 32 Issue: 2 p229-232, 4p
Publication Year :
1976

Abstract

A reciprocal translocation involving chromosomes Nos. 3 and 22 has been found in a patient with seemingly Ph'-negative chronic myelogenous leukemia (CML). G-band analysis revealed, that deletion in No. 22 occurred at the same point, as in the typical cases of the disease. It was concluded, that breakage in No. 22 at a specific site with spatial disjunction of the resulting segments might be the crucial cytogenetic event in the genesis of CML, the Philadelphia chromosome not being an obligatory result of the rearrangement.

Details

Language :
English
ISSN :
03406717 and 14321203
Volume :
32
Issue :
2
Database :
Supplemental Index
Journal :
Human Genetics
Publication Type :
Periodical
Accession number :
ejs15955531
Full Text :
https://doi.org/10.1007/BF00291511